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| Product Name | BLAME, Recombinant Human (B-lymphocyte activator macrophage expressed) |
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| Description | Purity ≥ 90% as determined by SDS-PAGE and visualized by silver stain. Endotoxin: ≤ 1.0 EU per 1ug of the protein as determined by the LAL method. Human BLAME (B-lymphocyte activator macrophage expressed), also known as SLAM family member 8, is a type I transmembrane protein that belongs to the CD2 subset of immunoglobulin superfamily cell receptors. CD2 family proteins function as adhesion molecules and modulators of immune responses. Mature human BLAME consists of a 211aa ECD that contains two Ig V-like domains, a 21aa transmembrane segment, and a 31aa cytoplasmic tail that lacks recognizable signaling motifs (3). Within the ECD, human BLAME shares 19-26% aa sequence identity with human 2B4, CD2, CD2F-10, CD48, CD58, CD84, CD229, CRACC, NTB-A, and SLAM. It shares 79% aa sequence identity with the ECD of mouse BLAME. BLAME is expressed on dendritic cells and IFN-γ stimulated monocytes. Overexpression of BLAME in bone marrow cells leads to an increase in the peritoneal B1b popula |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | B2106 |
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| Order / More Info | BLAME, Recombinant Human (B-lymphocyte activator macrophage expressed) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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