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| Product Name | Catechol-O-Methyltransferase (COMT), BioAssay™ ELISA Kit (Human) |
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| Description | Catechol-O-Methyltransferase (COMT), BioAssay™ ELISA Kit is a sandwich ELISA for quantitative detection of human COMT in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA). Catechol-O-methyltransferase (COMT) is one of several enzymes that degrade catecholamines such as dopamine, epinephrine, and norepinephrine. In humans, catechol-O-methyltransferase protein is encoded by the COMT gene. As the regulation of catecholamines is impaired in a number of medical conditions, several pharmaceutical drugs target COMT to alter its activity and therefore the availability of catecholamines. In the brain, COMT-dependent dopamine degradation is of particular importance in brain regions with low expression of the presynaptic dopamine transporter (DAT), such as the prefrontal cortex. This process is supposed to take place in postsynaptic neurons, as, in general, COMT is located intracellularly in the central nervous system (CNS). Assay Range: 31.2-2000pg/ml Sensitivity: <10pg/ml |
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| Size | 96 tests |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Gene ID: 1312, SwissProt: P21964 |
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| Catalog # | 352726 |
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| Order / More Info | Catechol-O-Methyltransferase (COMT), BioAssay™ ELISA Kit (Human) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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