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| Product Name | SFRP1, Recombinant, Human (FRP, FRP1, SARP2) |
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| Description | Purity ~97% (SDS-PAGE, HPLC). SFRP1 (Secreted Frizzled-Related Protein-1) is a widely expressed multi-functional secreted protein, and member of the sFRP family, which act as soluble modulators of Wnt signalling, playing an important role in embryonic development, and in proliferation, differentiation, and apoptosis in adult tissues. SFRP1 acts as a promoter of Wnt-induced effects at lower concentrations, and as a negative regulator at high concentrations, and has been implicated as a tumour suppressor protein in several human malignancies, including colorectal, breast, bladder, and ovarian cancer. Source: Recombinant protein corresponding to human SFRP1, expressed in HeLa cells. Molecular Weight: ~283kD Biological Activity: Determined by its ability to inhibit BMP-2 proliferation effect of ATDC-5 cells, with an expected ED50 of 0.3-0.5ug/ml. Applications: Suitable for use in Functional Assays. |
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| Size | 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Gene ID: 6422, SwissProt: Q8N474 |
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| Catalog # | 215121 |
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| Order / More Info | SFRP1, Recombinant, Human (FRP, FRP1, SARP2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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