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| Product Name | CDK2, Recombinant, Human, aa1-298, His-Tag (Cyclin-dependent Kinase 2) |
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| Description | Purity ~90% (SDS-PAGE). Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Cell division protein kinase 2, p33 protein kinase |
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| Gene, Accession, CAS # | SwissProt: P24941 |
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| Catalog # | 372698 |
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| Order / More Info | CDK2, Recombinant, Human, aa1-298, His-Tag (Cyclin-dependent Kinase 2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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