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| Product Name | CDK4, Recombinant, Human, aa2-303, His-Tag (Cyclin-dependent Kinase 4) |
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| Description | Purity ~90% (SDS-PAGE). Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Source: Recombinant protein corresponding to aa2-303 from human CDK4, fused to His-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~37.6kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Cell division protein kinase 4PSK-J3 |
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| Gene, Accession, CAS # | SwissProt: P11802 |
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| Catalog # | 372700 |
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| Order / More Info | CDK4, Recombinant, Human, aa2-303, His-Tag (Cyclin-dependent Kinase 4) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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