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| Product Name | IL-1alpha, Mouse, BioAssay™ ELISA Kit (Interleukin-1alpha IL-1F1) |
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| Description | The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not re- quired for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner Sample Type: Cell culture supernatants, serum and plasma Intended Use: The mouse |
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| Size | 96 tests |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 207234 |
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| Order / More Info | IL-1alpha, Mouse, BioAssay™ ELISA Kit (Interleukin-1alpha IL-1F1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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