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| Product Name | Receptor-interacting Serine/threonine-protein Kinase 3, Recombinant, Human, aa1-518, His-SUMO-Tag (RIPK3) |
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| Description | Purity ~90% (SDS-PAGE). Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. Source: Recombinant protein corresponding to aa1-518 from human Receptor-interacting serine/threonine-protein kinase 3, fused to His-SUMO-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~72.9kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q9Y572 |
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| Catalog # | 406032 |
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| Order / More Info | Receptor-interacting Serine/threonine-protein Kinase 3, Recombinant, Human, aa1-518, His-SUMO-Tag (RIPK3) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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