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| Product Name | IL-17A/F, Recombinant, Human (Interleukin-17A/F Heterodimer) |
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| Description | Purity ~98% (SDS-PAGE, HPLC). Human IL-17A/F is a 40kD glycoprotein which is secreted as a disulfide-linked heterodimer. IL-17A/F consists of two proteins, IL-17A and IL17F. Human IL17A is produced as a 155aa precursor that includes a 23aa signal sequence and a 132aa chain that includes an N-linked glycosylation site. Human IL17F is produced as a 153aa precursor with a 20aa signal sequence and a 133aa region and an N-linked glycosylation site. Both proteins (IL17A & IL17F) share 50% amino acid sequence identity. Human IL17A and IL17F show approximately 60% homology in their amino acid sequence to mouse IL-17A and IL-17F. Interleukin-17A/F and IL17A, IL17F homodimers are manufactured by activted CD4+ T cells, called Th17. IL-23 causes Th17 lymphocytes to manufacture IL-17A/F. Interleukin-17A/F induces chemokine production and airway neutrophilia with intermediate potency between IL17A (most potent) and IL17F (least potent). IL-17A/F Human Recombinant produced in E. coli is a heterodimer |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Human IL-17A/F, IL-17A/F, IL17A/F, IL 17 A/F, h-IL-17A/F, rh-IL-17A/F, recombinant human IL-17A/F, recombinant IL-17, IL, interluekin |
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| Gene, Accession, CAS # | IL17A;IL17F, SwissProt: IL17A-Q16552 |
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| Catalog # | 219908 |
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| Order / More Info | IL-17A/F, Recombinant, Human (Interleukin-17A/F Heterodimer) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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