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| Product Name | IL-17A/F, Recombinant, Human (Interleukin-17A/F Heterodimer) (Carrier free) |
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| Description | Purity ~98% (SDS-PAGE). IL-17A/F is a cystine-linked heterodimer of IL-17A and IL-17F (1,2). IL-17A/F is produced by Th17 cells, and y8 T cells (1,2). IL-17A/F stimulates the production of pro-inflammatory cytokines and neutrophil chemoattractants, thereby functioning as a bridge between adaptive and innate immunity (1-3). Some research studies suggest that IL-17A/F may be involved in mucosal immunity against some bacterial infections and has a putative role in some autoimmune disorders (3,4). The receptor for IL-17A/F consists of a heterodimer of IL-17RA and IL-17RC and signaling through this receptor leads to the activation of the Erk1/2 and NF-kB pathways (1). Source: Recombinant protein corresponding to human IL-17A/F, expressed in human 293 cells. Molecular Weight: ~31.396kD Biological Activity: Determined by its ability to induce mouse IL-6 production by 3T3 MEFs WT. The ED50 of each lot is 50-200ng/ml. Endotoxin: <0.01ng/1ug |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 137448 |
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| Order / More Info | IL-17A/F, Recombinant, Human (Interleukin-17A/F Heterodimer) (Carrier free) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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