| 产品详情 |
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| Product Name | 2-Chloro-5-nitro-N-4-pyridinylbenzamide (T0070907) |
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| Description | A cell-permeable chloro-nitro-benzamido compound that acts as a potent, specific, irreversible, and high-affinity antagonist of PPARγ with a Ki of 1nM. Displays >800-fold greater selectivity for PPARγ over PPARα and PPARδ (Ki = 0.85uM and 1.8uM, respectively). Blocks hormone- and agonist-induced adipogenesis in 3T3-L1 cells. It suppresses interactions between PPARγ and coactivator-derived peptides, while promotes the recruitment of corepressor-derived peptides. Shown to modulate the interaction of PPARγ2 with the cofactor proteins through covalent binding to Cys313 in its ligand-binding domain. Alternate Names: T0070907 |
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| Size | 5mg, 10mg, 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | T0070907 |
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| Gene, Accession, CAS # | CAS: 313516-66-4 |
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| Catalog # | C5029-18 |
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| Order / More Info | 2-Chloro-5-nitro-N-4-pyridinylbenzamide (T0070907) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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| 产品资料 |
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