| 产品详情 |
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| Product Name | STIMA-1 |
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| Description | Purity >97%. STIMA-1 (SH group-targeting compound that induces massive apoptosis) reactivates mutant p53. STIMA-1 can stimulate mutant p53 DNA binding in vitro and induce expression of p53 target proteins and trigger apoptosis in mutant p53-expressing human tumor cells. STIMA-1 is shown to covalently modify free thiols on mutant p53 in H1299-His175 cells and fully restore its DNA binding activity to the level seen with wild-type p53, resulting in upregulation of p53-dependent gene expression, including p21, PUMA, and Bax. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-Vinyl-4H-quinazolinol, SH group-targeting compound that induces massive apoptosis |
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| Gene, Accession, CAS # | CAS: 91634-12-7 |
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| Catalog # | LS-H3488 |
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| Order / More Info | STIMA-1 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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