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| Product Name | CD40L, Soluble, Recombinant, Human |
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| Description | Purity >95% (SDS-PAGE). CD40L is a high activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L in vivo. It provides a simple and equally potent alternative to combinations. CD40L has shown to suppress alum-induced IL-1beta release and caspase-1 activation in a dose-, CD40- and time dependent manner, without affecting BMDM viability. It also effectively suppressed the inflammasome function triggered by NLRP3 activators. The secretion of caspase-1 independent inflammatory mediators has been shown to be unaltered or even enhanced. Biological Activity: Induces B cells activation (as demonstrated by dose-dependent upregulation of CD86) (ED50: <1ng/ml). Sequence: Human CD40L (aa 116-261) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG®-tag. |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CD40L, Soluble, Recombinant, Human (ACRP30headless:CD40L, ACRP30headless:CD154, ACRP30headless:TNFSF5, ADIPOQ-CD40L) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 44659 |
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| Order / More Info | CD40L, Soluble, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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