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| Product Name | NME4, Recombinant, Human, aa1-187, GST-Tag (Nucleoside Diphosphate Kinase, Mitochondrial) |
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| Description | Purity ~90% (SDS-PAGE). Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis. Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity. Acts as mitochondria-specific NDK; its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration. Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria. In vitro can induce liposome cross-linking suggesting that it can cross-link inner and outer |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Nucleoside diphosphate kinase D |
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| Gene, Accession, CAS # | SwissProt: O00746 |
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| Catalog # | 374431 |
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| Order / More Info | NME4, Recombinant, Human, aa1-187, GST-Tag (Nucleoside Diphosphate Kinase, Mitochondrial) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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