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| Product Name | ST6GALNAC2, Recombinant, Mouse |
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| Description | Purity ~95% (SDS-PAGE). Sialic acid molecules attached to glycoproteins or glycosphingolipids play important roles in various biological processes such as immune recognition, pathogen infection, and cell adhesion. Sialyltransferases are key enzymes that regulate the serum levels of sialic acid-containing molecules. Alpha-N-acetylgalactosaminide a-2,6-sialyltransferase 2, encoded by the ST6GALNAC2 gene, is a type II membrane protein localized in the Golgi network and catalyzes 2,6-sialylation of the Tn antigen (GalNAc-O-Ser/Thr) (1). Sialyl-Tn antigen is highly expressed in several human carcinomas and is associated with carcinoma aggressiveness and poor prognosis. Cells transfected with ST6GALNAC2 synthesized the sialyl-6T structure [GalB1-3 (Neu5Aca2-6) GalNAc-O-Ser/Thr] (2). In vitro analysis revealed that the enzyme can use both GalB1-3GalNAc and Neu5Aca2-3GalB1-3GalNAc as acceptor substrates (3). Recently, it has been reported that disregulation of this gene is involved in the path |
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| Size | 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ST6GALNAC2, Recombinant, Mouse (6468-GT-020Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2, Gal-beta-1,3-GalNAc alpha-2,6-sialyltransferase, GalNAc alpha-2,6-sialyltransferase II, ST6GalNAc II, ST6GalNAcII, Sialyltransferase 7B, SIAT7-B, Siat7, Siat7b) |
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| Gene, Accession, CAS # | SwissProt: P70277 |
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| Catalog # | S0550-04 |
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| Order / More Info | ST6GALNAC2, Recombinant, Mouse from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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