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| Product Name | ST6GALNAC5, Recombinant, Human, 6-His-Tag |
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| Description | Purity ~95% (SDS-PAGE). Gangliosides are acidic glycosphingolipids that contain one or more sialic acid residues. They are abundant in the nervous system, where they play crucial modulatory roles in cellular recognition, interaction, adhesion, and signal transduction, particularly during early developmental stages. The expression of gangliosides in the nervous system is developmentally regulated through various sialyltransferases. ST6GALNAC5 is a sialyltransferase involved in the biosynthesis of ganglioside GD1a (NeuAca2,3GalB1,3GalNAcB1, 4(NeuAcA2,3)GalB1, 4GlcB1-Cer) from GM1b (NeuAcA2,3GalB1,3GalNAcB1,4GalB1,4GlcB1-Cer), and its expression is restricted to the brain. ST6GALNAC5 has been identified as a key player in the metastasis of breast cancer cells to the brain by potentially enabling the cancer cells to cross the blood-brain barrier. The recombinant ST6GALNAC5 was active on fetuin from fetal calf serum when assayed using a phosphatase-coupled method suggesting the substrate sp |
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| Size | 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ST6GALNAC5, Recombinant, Human, 6-His-Tag (Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5, GD1 alpha Synthase, GalNAc alpha-2,6-sialyltransferase V, ST6GalNAc V, ST6GalNAcV, Sialyltransferase 7E, SIAT7-E, SIAT7E) |
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| Gene, Accession, CAS # | SwissProt: Q9BVH7 |
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| Catalog # | S0550-07 |
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| Order / More Info | ST6GALNAC5, Recombinant, Human, 6-His-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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