| 产品详情 |
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| Product Name | AMPA Agonist, CMPA |
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| Description | Purity ~98% (HPLC). A bisalykylsulfonamide that acts as a positive, allosteric modulator against AMPA receptors (EC50 = 45nM and 63nM for GluA2i and GluA2o, respectively) in a HEK 293 calcium FLIPR assay. At 10uM, it robustly modulates receptor desensitization of both the flip (GluA2i) and flop (GluA2o) isoforms of GluA2 receptors in transfected HEK 293 cells with higher potency and efficacy than two other distinct AMPA modulators, cyclothiazide and CX614. Using a ligand bound crystal structure, it is shown to bind to the dimer interface of the extracellular ligand-binding domain of AMPA receptors, a region that partially overlaps with binding pockets for cyclothiazide and CX614. Formula: C16H28N2O4S2 Molecular Weight: 376.5 Solubility: DMSO (100mg/ml, clear, nearly colorless solution) |
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| Size | 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | AMPA Agonist, CMPA (AMPA Activator, N,N'-(2,2'-(1,4-phenylene)bis(ethane-2,1-diyl))dipropane-2-sulfonamide) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217175 |
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| Price | |
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| Order / More Info | AMPA Agonist, CMPA from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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