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| Product Name | MAGP2, Recombinant, Human, 6-His-Tag |
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| Description | Purity ~95% (SDS-PAGE). MAGP-2 (Microfibril-associated glycoprotein 2), also called MFAP5 (microfibril associated protein 5) is a secreted, cell-associated 25kD mammalian member of the MFAP family of proteins. Human MAGP-2 cDNA encodes 173aa including a 21aa signal sequence, an RDG motif aa30-32; absent in MAGP-1) and a central cysteine-rich binding domain aa84-140. One potential splice variant shows a 10aa deletion between aa73-82 that includes the only potential glycosylation site. Mature human MAGP-2 shares 80%, 82%, 82%, 84% and 85% aa identity with mouse, rat, bovine, porcine and canine MAGP-2, respectively. Both MAGP-1 and MAGP-2 bind and covalently crosslink fibrillins 1 and 2 through the binding domain, but MAGP-2 has more limited distribution and binds a more limited set of extracellular matrix proteins. However, the MAGP-2 RGD motif binds to the integrin av b3, allowing cell attachment to microfibrils. MAGP-2 is thought to facilitate microfibril assembly and induce elastin fi |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | MAGP2, Recombinant, Human, 6-His-Tag (Microfibril-associated Glycoprotein 2, MAGP-2, Microfibrillar-associated Protein 5, MFAP5, MFAP-5, MP25) |
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| Gene, Accession, CAS # | SwissProt: Q13361 |
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| Catalog # | M2125-16 |
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| Order / More Info | MAGP2, Recombinant, Human, 6-His-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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