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| Product Name | β-Amyloid Precursor Protein, Human (APP770) (Control Peptide) |
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| Description | Highly purified. Anti-human APP770 was raised using a synthetic 15-aa peptide near the extracellular, KPI-region (301-316 aa) of human APP770 (1). Peptide was conjugated to KLH. Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by progressive loss of memory and cognition in the elderly. One of the most important and initial step involves proteolytic cleavage of amyloid precursor protein (APP, chromosome 21) releasing short 40, 42 & 43 aa peptides (beta amyloid1-40,1-42, and 1-43; approx. 4.5kD). Polymerization of b-amyloid (Ab) and subsequent neuronal deposit (amyloid) leads to the degeneration of neurons involved in memory and cognition. Ab deposits have also been found to contain 2 additional proteins termed a-synuclein and b-synuclein. APP gene has 19 exons (1). At least 8 different types of APP (APP695, APP751, and APP770 are the major ones) are produced as a result of alternative splicing of exons 7, 8, and 15. Exons 7 codes for a 57-aa domain that is analogou |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | A2275-86K |
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| Order / More Info | β-Amyloid Precursor Protein, Human (APP770) (Control Peptide) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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