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| Product Name | DPH2, Recombinant, Human, aa1-489, His-Tag (Diphthamide Biosynthesis Protein 2, DPH2L2) |
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| Description | Purity ~85% (SDS-PAGE). DPH2, also known as diphthamide biosynthesis protein 2, is a homodimer and each of its monomers can bind a [4Fe-4S] cluster. It is the target of ADP ribosylating diphtheria toxin (DT) and Pseudomonas exotoxin A (PE). It was identified by its ability to complement a diphthamide mutant strain, and thus functions in diphthamide biosynthesis. Its loss pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor. Source: Recombinant protein corresponding to aa1-489 from human DPH2, fused to His-Tag at C-terminal, expressed in insect cell. Molecular Weight: ~53.1kD (497aa) 50-70kD (SDS-PAGE under reducing conditions) Endotoxin: <1EU/1ug (determined by LAL method) AA |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NP_001375 |
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| Catalog # | 377788 |
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| Order / More Info | DPH2, Recombinant, Human, aa1-489, His-Tag (Diphthamide Biosynthesis Protein 2, DPH2L2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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