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| Product Name | ATPase, Ca, Rat, Control Peptide (Plasma Membrane, PMCA) |
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| Description | Chromatographically purified. A 20aa Peptide sequence near the N-terminus of mature Rat NCKX2 (1) was selected for antibody production. Ca2+ plays a critical role in intracellular signaling. Intracellular Ca2+ levels are tightly controlled by continuos removal of Ca2+ via ATP-driven Ca2+ pump in the endoplasmic reticulum and plasma membrane, and Ca2+ transport system, the Na+/Ca2+ exchangers (NCX), in the plasma membrane. NCX can move Ca2+ either into or out of cells, depending on the net Na+, Ca2+, and K+ gradient across the membrane. In most cells, 3 Na+ are exchanged for 1 Ca2+. In mammals, at least 5 distinct genes code for the exchangers- Three NCX (NCX1, NCX2, and NCX3) and two in the NCKX family (NCKX1 and NCKX2). NCX shares significant sequence homology (~70%), displays 11 TM domains, a large central, intracellular hydrophilic regulatory loop between TM5 and 6, extracellular N-terminus and cytoplasmic C-terminus. The N-terminal signal peptide is cleaved off from the mature exch |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | ELISA WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | A4000-50H |
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| Order / More Info | ATPase, Ca, Rat, Control Peptide (Plasma Membrane, PMCA) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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