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| Product Name | CD40LG, Recombinant, Human, aa47-261, His-Tag (CD40 Ligand) |
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| Description | Purity ~90% (SDS-PAGE). Cytokine that binds to CD40/TNFRSF5 (PubMed:1280226). Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway. Source: Recombinant protein corresponding to aa47-261 from human CD40LG, fused to His-Tag at N-terminal, expressed in Yeast. Molecular Weight: ~26.1kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | T-cell antigen Gp39 ,TNF-related activation protein,TRAP, Tumor necrosis factor ligand superfamily member 5, CD_antigen, CD154 Cleaved into the following 2 chains: CD40 ligand, membrane form CD40 ligand, soluble form |
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| Gene, Accession, CAS # | SwissProt: P29965 |
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| Catalog # | 372671 |
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| Order / More Info | CD40LG, Recombinant, Human, aa47-261, His-Tag (CD40 Ligand) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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