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| Product Name | Pepsinogen II (PGII, PGC, Pepsinogen C, EC 3.4.23.3, Gastricin), Human |
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| Description | Purity ≥ 90% (SDS-PAGE; may contain minor cleavage products). Identity confirmed by Western blot. Pepsinogen II or pepsinogen C belongs to a group of aspartic proteinase zymogens (inactive form) that are activated in the acid pH of stomach to active enzyme pepsin. Pepsinogen II (PG II) is produced by chief cells and mucus neck cells of gastric mucosa, pyloric glands in the antrum and Brunner's glands in the proximal duodenum. Serum concentration of PG II reflects the histological status of gastric mucosa. The ratio of concentration of PGI to PGII in serum of normal subjects is about 4:1. The PGI/PGII ratio decreases linearly with increasing grade of atrophic gastritis in the corpus. The ratio is < 2.5 when the atrophic gastritis is advanced (moderate or severe) in the gastric corpus. Solubility: Clear colorless liquid at 1mg/mL in saline Specific Activity: Lot-dependent. ≥1,000U/mg protein (upon activation) Note: Pepsinogen self-activates upon exposure to low pH. Unit Definition of Act |
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| Size | 100ug, 1mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Gene ID: 5225, SwissProt: P20142 |
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| Catalog # | P3272-09 |
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| Order / More Info | Pepsinogen II (PGII, PGC, Pepsinogen C, EC 3.4.23.3, Gastricin), Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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