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| Product Name | NEIL1, Recombinant, Human, aa2-390, His-SUMO-Tag (Endonuclease 8-like 1) |
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| Description | Purity ~90% (SDS-PAGE). Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and roves damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the roved base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Source: Recombinant protein corresponding to aa2-390 from human NEIL1, fused to His-SUMO-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~59.6kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | DNA glycosylase/AP lyase, Neil1 DNA-(apurinic or apyrimidinic site) lyase Neil1 Endonuclease VIII-like 1FPG1Nei homolog 1, NEH1Nei-like protein 1 |
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| Gene, Accession, CAS # | SwissProt: Q96FI4 |
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| Catalog # | 374399 |
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| Order / More Info | NEIL1, Recombinant, Human, aa2-390, His-SUMO-Tag (Endonuclease 8-like 1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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