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| Product Name | PKAca, Active, Recombinant, Human |
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| Description | Purity ~90% (SDS-PAGE). Most of the effects of cAMP are mediated through the phosphorylation of target proteins on serine or threonine residues by the cAMP-dependent protein kinase (AMPK). The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. The mammalian catalytic subunit has been shown to consist of three PKA gene products: C-alpha, C-beta, and C-gamma. Two PKA isoforms exist, designated types I and II, which differ in their dimeric regulatory subunits, designated RI and RII, respectively. Furthermore, there are at least four different regulatory subunits: RI-alpha, RI-beta, RII-alpha, and RII-beta. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. The catalytic subunit C-alpha of PKA (PKAca) is a member of the Ser/Thr protein kinase family and is a catalytic subunit C-beta of AMPK. Tasken et al. assigned the PKAca gene to 19p13.1 (1) |
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| Size | 5ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PKAca, Active, Recombinant, Human (cAMP-dependent Protein Kinase Catalytic Subunit alpha, PKA C-alpha, PRKACA) |
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| Gene, Accession, CAS # | PRKACA, Gene ID: 5566, Accession: NM_002730 |
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| Catalog # | 220163 |
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| Order / More Info | PKAca, Active, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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