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| Product Name | GDF-5, Recombinant, Mouse (BMP-14, Cartilage-Derived Morphogenetic Protein-1 (CDMP-1)) |
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| Description | Purity ≥98% by SDS-PAGE gel and HPLC analyses. GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the GDF-5 gene have been implicated in Grebe Syndrome, which is characterized by short stature, extra digits, short and deformed extremities, and in Hunter-Thompson type dwarfism. The mature and functional form of GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Each GDF-5 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino-acid signal peptide and a 348 amino-acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease. Recombinant murine GDF-5 is a 27.0kD homodimeric disulfide-linked protein consisting of two 120 amino acids. Biological Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for |
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| Size | 10ug, 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 143345 |
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| Order / More Info | GDF-5, Recombinant, Mouse (BMP-14, Cartilage-Derived Morphogenetic Protein-1 (CDMP-1)) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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