| 产品详情 |
| Edit |   |
|---|
| Product Name | Integrin alpha 2b beta 3, Recombinant, Human (alphaIIbbeta3, GPIIbIIIa, CD41) |
|---|
| Description | Purity ~95% (SDS-PAGE). Endotoxin: <1.0EU/ug protein (LAL method). Integrin alpha2bbeta3 (also alphaIIbbeta3 or GPIIbIIIa) is the only alpha2b integrin and shares the beta3 subunit only with alphaVbeta3 (1-3). It is the non-covalent heterodimer of type I transmembrane subunits, alpha2b/CD41 (present as a disulfide-linked complex of 114kD heavy and 22kD light chains) and 93kD beta3/CD61 (1-3). It is the most abundant integrin expressed by megakaryocytes and platelets, both on the surface and within alpha granules (1, 2). Deficiencies of alpha2bbeta3 produce Glanzmann thrombasthenia, a potentially serious bleeding disorder (4). In its constitutively inactive state, alpha2bbeta3 is flexed within the extracellular domains. Activation, either by intracellular signaling or by Mg2+ or Mn2+ binding, extends the integrin to expose the ligand binding site created by interaction of the beta3 vWFA domain with the alpha2b beta-propeller structure (1). The 962aa human alpha2b ECD shares 78-83% aa se |
|---|
| Size | 25ug |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | n/a |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | 145809 |
|---|
| Price | |
|---|
| Order / More Info | Integrin alpha 2b beta 3, Recombinant, Human (alphaIIbbeta3, GPIIbIIIa, CD41) from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|