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| Product Name | Integrin alpha 2 beta 1, Recombinant, Mouse |
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| Description | Purity ~95% (SDS-PAGE). Integrin alpha2beta1 is one of twelve integrin family adhesion receptors that share the beta1 subunit (13). It is the noncovalent heterodimer of 160kD alpha2 (CD49b) and 130kD beta1 (CD29) type I transmembrane glycoprotein subunits. It is one of six very late antigens on activated T cells, designated VLA2 (3). The alpha2 extracellular domain (ECD) contains an I (inserted) domain which includes the ligand binding site (2, 3). The beta1 ECD contains a vWFA domain, which participates in binding. Each subunit then has a transmembrane sequence and a short cytoplasmic tail. The dimer is folded when it is least active. Divalent cations and intracellular (insideout) signaling convert it to its most active, extended and open conformation (1, 2). The 1103 amino acid (aa) mouse alpha2 extracellular domain (ECD) shares 93% aa sequence identity with rat and 8081% with human, canine, bovine and equine alpha2, while the 708 aa mouse beta1 ECD shares 98% aa identity with r |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 145808 |
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| Order / More Info | Integrin alpha 2 beta 1, Recombinant, Mouse from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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