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| Product Name | Integrin alpha 10 beta 1, Recombinant, Mouse, aa23-1119 |
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| Description | Purity ~95% (SDSPAGE). Integrin alpha10beta1 is one of twelve integrin family adhesion receptors that share the beta1 subunit (13). The noncovalent heterodimer of 160kD alpha11 and 130kD beta1/CD29 type I transmembrane glycoprotein subunits is expressed mainly on chondrocytes within cartilage, but also in fibrous connective tissues such as heart valves and ligaments (3, 4). The alpha10 extracellular domain (ECD) contains an I (inserted) domain which includes the ligand binding site (2, 3, 5). The beta1 ECD contains a vWFA domain, which participates in binding. Each subunit then has a transmembrane sequence and a short cytoplasmic tail. The dimer is folded when it is least active. Divalent cations and intracellular (insideout) signaling convert it to its most active, extended and open conformation (1, 2). The 1100 amino acid (aa) mouse alpha10 extracellular domain (ECD) shares 96% aa sequence identity with rat and 8889% with human, rabbit, porcine, canine and bovine alpha10, while |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 145806 |
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| Order / More Info | Integrin alpha 10 beta 1, Recombinant, Mouse, aa23-1119 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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