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| Product Name | TGF-beta1 BioAssay™ ELISA Kit (Human) |
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| Description | Transforming growth factor (TGF), a `factor' that promoted the transformation of cultured fibroblasts into a tumor-like phenotype, was subsequently found to be more of a tumor suppressor than tumor promoter and to be a mixture of two proteins, TGF-alpha and TGF-beta. Human TGF-beta1 is a 25kD, disulfide-linked, non-glycosylated homodimer. There is nearly 100% sequence conservation across mammalian species. Biological activity requires release of TGF-beta1 from the latent complex. This can be done in vitro by disruption of LAP (e.g. acidification). There are, however, three fundamental activities: TGF-beta1 modulates cell proliferation, generally as a supressor; TGF-beta1 enhances the deposition of extracellular matrix through promotion of synthesis and inhibition of degradation; TGF-beta1 is immunosuppressive through a variety of mechanisms. The specific action of TGF-beta on a particular cell depends on the exact circumstances of that cell's environment. Sample Type: Cell culture supe |
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| Size | 96 tests |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | TGF-beta1 BioAssay™ ELISA Kit (Human) (Transforming growth factor beta-1, TGF-beta-1, TGFB1, TGFB, TGF beta1, TGFbeta1) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 361301 |
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| Order / More Info | TGF-beta1 BioAssay™ ELISA Kit (Human) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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