| 产品详情 |
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| Product Name | EGF Receptor, phosphorylated BioAssay™ Sample Kit |
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| Description | Purified by Protein A and peptide affinity chromatography. The epidermal growth factor (EGF) receptor is a 170 kD transmembrane tyrosine kinase and member of the HER/ErbB protein family. Ligand binding results in receptor dimerization, autophosphorylation, activation of downstream signaling and lysosomal degradation (1,2). The SH2 domain of PLC-g binds at phospho-Tyr992, resulting in activation of PLC-g-mediated downstream signaling (6). Phosphorylation of Tyr1045 creates a major docking site for c-Cbl, an adaptor protein that leads to receptor ubiquitination and degradation following EGFR activation (7,8). The GRB2 adaptor protein binds activated EGFR at phospho-Tyr1068 (9). A pair of phosphorylated residues (Tyr1148 and Tyr1173) provide a docking site for the SHC scaffold protein, with both sites involved in MAP kinase signaling activation (2). Phosphorylation of EGFR at specific serine and threonine residues attenuates EGFR kinase activity. EGFR carboxy-terminal residues Ser1046 and |
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| Size | 1 kit |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | E3375-60 |
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| Order / More Info | EGF Receptor, phosphorylated BioAssay™ Sample Kit from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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