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| Product Name | EGF Receptor, Recombinant, Human (EGFR, ErbB1) |
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| Description | Purity ≥95% by SDS-PAGE gel and HPLC analyses. EGF Receptor (EGFR, ErbB1) is a transmembrane protein that exerts tyrosine kinase activity upon ligand induced activation. EGFR can be activated by binding EGF or at least six other structurally related protein ligands, including TGFalpha, HB-EGF, Betacellulin (BTC), Amphiregulin, Epiregulin, and Epigen. Upon activation, EGFR initiates a signaling cascade which includes dimerization and internalization, tyrosine phosphorylation, DNA synthesis of target genes, and, ultimately, cell proliferation. EGFR signaling plays a role in the growth and differentiation of normal cells, but elevated EGFR activity is correlated with the development and pathogenesis of certain cancers. Recombinant soluble human EGFR is a 621 amino acid glycoprotein comprising the extracellular domain of EGFR, and migrates at an apparent MW of 97.5kD by SDS-PAGE analysis under reducing conditions. AA Sequence: LEEKKVCQGT SNKLTQLGTF EDHFLSLQRM FNNCEVVLGN LEITYVQRNY DLSFLKTI |
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| Size | 2ug, 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 143309 |
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| Order / More Info | EGF Receptor, Recombinant, Human (EGFR, ErbB1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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