| 产品详情 |
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| Product Name | EGF Receptor, Recombinant, Human (Epidermal Growth Factor Receptor, ErbB1) |
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| Description | Purity ~95% (SDS-PAGE). EGF Receptor (EGFR, ErbB1) is a transmembrane protein that exerts tyrosine kinase activity upon ligand induced activation. EGFR can be activated by binding EGF or at least six other structurally related protein ligands, including TGFalpha, HBEGF, Betacellulin (BTC), Amphiregulin, Epiregulin, and Epigen. Upon activation, EGFR initiates a signaling cascade which includes dimerization and internalization, tyrosine phosphorylation, DNA synthesis of target genes, and, ultimately, cell proliferation. EGFR signaling plays a role in the growth and differentiation of normal cells, but elevated EGFR activity is correlated with the development and pathogenesis of certain cancers. Recombinant soluble human EGFR is a 621aa glycoprotein comprising the extracellular domain of EGFR, and migrates at an apparent MW of 97.5kD by SDS-PAGE analysis under reducing conditions. Source: Recombinant protein corresponding to soluble human EGF Receptor, expressed in CHO cells. Molecular We |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ErbB1 |
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| Gene, Accession, CAS # | EGFR, SwissProt: P01133 |
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| Catalog # | 219708 |
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| Order / More Info | EGF Receptor, Recombinant, Human (Epidermal Growth Factor Receptor, ErbB1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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