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ALK2, Recombinant, Human, GST-Tag (Activin A Receptor Type I, ACVR1, ACTRI, ACVR1A, ACVRLK2, FOP, SKR1, TSRI) from UNITED STATES BIOLOGICAL |
| 产品详情 |
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| Product Name | ALK2, Recombinant, Human, GST-Tag (Activin A Receptor Type I, ACVR1, ACTRI, ACVR1A, ACVRLK2, FOP, SKR1, TSRI) |
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| Description | Purified (~70-90%). ALK 2 is a receptor serine/threonine kinase that is member of the ALK family and is upstream of signaling pathway involving the SMAD proteins especially SMAD1/5/8. Knockdown of ALK2, but not TGFbetaRI (ALK5), abrogates endoglin-mediated decrease in cell motility of prostate cancer cells and constitutively active ALK2 is sufficient to restore a low-motility phenotype in endoglin deficient cells. Therefore, endoglin decreases prostate cancer cell motility through activation of the ALK2-Smad1 pathway. ALK2 is the key gene involved in Fibrodysplasia ossificans progressiva (FOP), a rare autosomal dominant congenital disorder characterized by progressive heterotopic bone formation in muscle tissues. Source: Recombinant protein corresponding to human ALK2, fused to GST-Tag at N-terminal, expressed in Insect cells. Molecular Weight: ~67kD Specific Activity: 39nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NM_001105 |
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| Catalog # | 499773 |
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| Order / More Info | ALK2, Recombinant, Human, GST-Tag (Activin A Receptor Type I, ACVR1, ACTRI, ACVR1A, ACVRLK2, FOP, SKR1, TSRI) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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