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| Product Name | Gremlin-1, Recombinant, Human (CKTSF1B1, DAND2, DRM, IHG-2) |
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| Description | Purity ~90% (SDS-PAGE). Gremlin-1 (isoform-1) belongs to a group of diffusible proteins which bind to ligands of the TGF-beta family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-beta ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Gremlin is highly expressed in the small intestine, fetal brain, and colon and lower expression in brain, prostate, pancreas and skeletal muscle. Gremlin-1 regulates multiple functions in early development by specifically binding to and inhibiting the function of BMP-2, -4, and -7. It also plays a role in carcinogenesis and kidney branching morphogenesis. Source: Recombinant protein corresponding to 160aa residues from human Gremlin-1, expressed in CHO cells. Molecular Weight: ~18.3kD Biological Activity: Determined by its ability to |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CKTSF1B1, DAND2, DRM, IHG-2 |
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| Gene, Accession, CAS # | Grem1, Gene ID: 23892, Accession: O70326 |
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| Catalog # | 219813 |
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| Order / More Info | Gremlin-1, Recombinant, Human (CKTSF1B1, DAND2, DRM, IHG-2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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