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| Product Name | HOMER1, Recombinant, Human, aa1-354, His-Tag (Homer Protein Homolog 1) |
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| Description | Purity ~90% (SDS-PAGE). Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic domain regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Source: Recombinant protein corresponding to aa1-354 from human HOMER1, fused to His-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~44.3kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q86YM7 |
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| Catalog # | 373674 |
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| Order / More Info | HOMER1, Recombinant, Human, aa1-354, His-Tag (Homer Protein Homolog 1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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