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| Product Name | NF-kB Activation Inhibitor VIII, A-UBI (NEMO Ubiquitin Binding Domain Inhibitor) |
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| Description | Purity ~95% (HPLC). A cell-permeable 37-mer peptide derived from the NEMO NOA ubiquitin binding site (294-314 of mouse sequence with D304R), and fused with an Antennapedia cell penetrating protein (A) at the N-terminus. It is shown to attenuate NF-kB activation via blocking interactions between K63-polyubiquitin chains and the NOA ubiquitin binding domain of NEMO (=17uM for CC2-LZ/A-UBI complex). The biotin-labled A-UBI specifically inhibits the LPS-induced NF-kB activation (IC50=1.1uM, compared with 23uM for IKKb derived A-NBD) and TNF-a induced NF-kB activation (IC50=21uM) in 70Z/3-C3 pre-B lymphocytes. It displays an inhibitory effect on nuclear translocation of NF-kB p65 and IKK kinase activity at 10uM, but does not significantly affect other signaling pathways such as MAPK/ERK, MAPK/JNK, NF-kB and NFAT. Formula: C215H347N71O50S1 plus TFA and H2O Sequence: RQIKIWFQNRRMKWKKLKAQADIYKARFQAERHAREK Molecular Weight: 4758.6 Solubility: H2O (50mg/ml) |
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| Size | 2mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217587 |
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| Order / More Info | NF-kB Activation Inhibitor VIII, A-UBI (NEMO Ubiquitin Binding Domain Inhibitor) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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