| 产品详情 |
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| Product Name | NF-kB Activation Inhibitor VIII, EVP4593 |
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| Description | Purity ~98% (HPLC). A cell-permeable quinazoline derivative that blocks PMA/PHA-induced NF-kB activation in Jurkat cells (IC50=11nM), but has no effect on PKC kinase, and exhibits an anti-inflammatory effect on carrageenin-induced paw edema in rats (1mg/kg, i.p.). In addition, it is shown to inhibit the store-operated calcium entry (SOC) pathway possibly by targeting TRPC1 containing heteromeric channels in Huntington Disease (HD) neurons (SK-N-SH cells transfected with mutant Huntingtin Htt-138Q) at 300nM. It displays neuroprotective effects in YAC128 MSN mice neurons from glutamate toxicity dose-dependently from 30nM to 3uM, which is consistent with TRPC1 knocown effects, and attenuates the progressive decline in the climbing speed of the HD Drosophila, dose-dependently from 100uM to 400uM. Formula: C22H20N4O Molecular Weight: 356.4 Solubility: DMSO (100mg/ml clear, yellow solution) |
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| Size | 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | NF-kB Activation Inhibitor VIII, EVP4593 (SOC Inhibitor, Neuronal Store-Operated Calcium Entry Inhibitor, N4-(4-phenoxyphenethyl)quinazoline-4,6-diamine, TRPC1 Inhibitor) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217588 |
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| Order / More Info | NF-kB Activation Inhibitor VIII, EVP4593 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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