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TNF-alpha, BioAssay™ ELISApot Development Module (Rat) (Cachetin, DIF, TNF, tnfa, tnf-a, TNFSF1A, TNFSF2) from UNITED STATES BIOLOGICAL |
| 产品详情 |
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| Product Name | TNF-alpha, BioAssay™ ELISApot Development Module (Rat) (Cachetin, DIF, TNF, tnfa, tnf-a, TNFSF1A, TNFSF2) |
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| Description | Tumor necrosis factor alpha (TNF-alpha), also known as cachectin and TNFSF1A, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, apoptosis, and immune system development. TNF-alpha is produced by a wide variety of immune and epithelial cell types. Human TNF-alpha consists of a 35 amino acid (aa) cytoplasmic domain, a 21aa transmembrane segment, and a 177aa extracellular domain (ECD). Within the ECD, human TNF-alpha shares 97% aa sequence identity with rhesus and 71%-92% with bovine, canine, cotton rat, equine, feline, mouse, porcine, and rat TNF-alpha. The 26kD type 2 transmembrane protein is assembled intracellularly to form a noncovalently linked homotrimer. Ligation of this complex induces reverse signaling that promotes lymphocyte costimulation but diminishes monocyte responsiveness. Cleavage of membrane bound TNF-alpha by TACE/ADAM17 releases a 55kD soluble trimeric form of TNF-alpha. TNF-alpha trimers bind the |
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| Size | 1 kit |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 145770 |
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| Order / More Info | TNF-alpha, BioAssay™ ELISApot Development Module (Rat) (Cachetin, DIF, TNF, tnfa, tnf-a, TNFSF1A, TNFSF2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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