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| Product Name | PKC zeta, Active, Recombinant, Human (Protein Kinase C, zeta) |
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| Description | Purity ~90% (SDS-PAGE). PKCz (PKC zeta) is an atypical isoform of the PKC family. PKCz is found in both particulate and soluble fractions and cannot be activated by phorbol ester. Treatment of cells with phorbol ester which activates PKCalpha, gamma, delta, and epsilon isoforms in NIH3T3 cells significantly reduced proliferation of cells. Overexpression of PKCz and subsequent phorbol ester treatment abolished phorbol ester-induced reduction in cell proliferation (1). Overexpression of PKCz also potentiated phorbol ester-induced mitogen-activated protein (MAP) kinase activation in a PKC-dependent manner. The effects of PKCz overexpression on proliferation and MAP kinase activation are proportional to the levels of PKCz expression. PKCz as an upstream modulator of p70S6K, an important regulator of cell proliferation (2). Kinase-inactive PKCz mutant antagonized activation of p70S6K by epidermal growth factor, PDK-1, and activated Cdc42 and PI3-K. Overexpression of a constitutively active |
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| Size | 5ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Active PKCzeta, PKCzeta, PKCz, PKC-z, human PKCzeta, active kinase, active kinases, PKC, recombinant PKCzeta, recombinant PKC, kinase activity assay, protein kinase |
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| Gene, Accession, CAS # | PKCZ, Gene ID: 5590, SwissProt: Q05513 |
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| Catalog # | 220170 |
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| Order / More Info | PKC zeta, Active, Recombinant, Human (Protein Kinase C, zeta) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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