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| Product Name | AcCoA Carboxylase 1, Human, Control Peptide (ACC-1, Acetyl Coenzyme A Carboxylase 1) |
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| Description | Highly purified. Control Peptide for A0225-01A (affinity purified antibody) and A0225-01B (antiserum). In cells, excess of metabolic fuel is converted into fatty acids in cytosol and oxidized later in mitochondria to generate ATP and acetyl-CoA. In fatty acid synthesis, catalytic formation of malonyl-CoA (precursor for long-chain fatty acyl-CoA, LCFA-CoA) from acetyl-CoA by Acetyl-CoA carboxylase (ACC-1) is the rate limiting step. The translocation of LCFA-CoA from cytosol to mitochondria is catalyzed by two carnitine palmitoyl transferases (CPT-1 & CPT-2) and regulated by ACC-2, the rate limiting step of mitochondrial fatty acid b-oxidation. Activities of ACC-1 and 2 are regulated by their phosphorylation by 5'-AMP-activated protein kinase (AMPK). Diabetes deranges AMPK master-switch and represses the ACC-1 gene-expression and stimulates excessive fatty acid oxidation which in turn interferes with glucose metabolism. ACC1 is also known as ACC-alpha is a cytosolic enzyme, enriched in l |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | A0225-01 |
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| Order / More Info | AcCoA Carboxylase 1, Human, Control Peptide (ACC-1, Acetyl Coenzyme A Carboxylase 1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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