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| Product Name | IL-21, Recombinant, Human, Animal Free (Interleukin-21) |
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| Description | Purity ~98% (SDS-PAGE gel, HPLC). Endotoxin: ≤0.1ng/ug of protein (≤1EU/ug). IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation.Its action generally enhances antigen-specific responses of immune cells.The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells, stimulation (in conjuction) with IL-4 of IgG production, and induction of apoptotic effects in naiumlve B-cells and stimulated B-cells in the absence of T-cell signaling.Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells.IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the gamma chain (gammac) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15.The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the tran |
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| Size | 2ug, 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 208650 |
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| Order / More Info | IL-21, Recombinant, Human, Animal Free (Interleukin-21) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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