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| Product Name | IL11, Recombinant, Human (IL-11, Adipogenesis Inhibitory Factor, AGIF, INN=Oprelvekin, Interleukin-11) |
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| Description | Purity ~95% (SDS-PAGE). IL11 is secreted by bone marrow stromal cells (fibroblasts) and is produced also by a number of mesenchymal cells. The IL11 receptor (alpha chain) utilizes gp130 as its signal transducer, which is also a component of other cytokine receptors. The alpha chain of the IL11 receptor has been identified independently as Etl2. IL-1 promotes primary and secondary immune responses in vitro and in vivo and modulates antigen-specific antibody reactions. IL11 promotes the proliferation of IL6 dependent plasmacytoma cell lines in the presence of neutralizing IL6 antibodies. IL11 also stimulates the T cell dependent development of IgG-secreting B cells in spleen cell cultures. IL11 inhibits the differentiation of pre-adipocytes. It induces the synthesis of some acute phase proteins by hepatocytes. Source: Recombinant protein corresponding to human IL11 expressed in E. coli. Molecular Weight: ~19kD Biological Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of |
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| Size | 10ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P20809 |
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| Catalog # | 500103 |
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| Order / More Info | IL11, Recombinant, Human (IL-11, Adipogenesis Inhibitory Factor, AGIF, INN=Oprelvekin, Interleukin-11) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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