| 产品名称 |
IL10, Recombinant, Human (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF, B-TCGF, TGIF, Interleukin-10) from UNITED STATES BIOLOGICAL |
| 产品详情 |
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| Product Name | IL10, Recombinant, Human (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF, B-TCGF, TGIF, Interleukin-10) |
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| Description | Purity ~95% (SDS-PAGE). In humans, IL10 is produced by activated CD8(+) peripheral blood T-cells, by T-helper CD4(+) T cell clones after both antigen-specific and polyclonal activation, by B cell lymphomas, and by monocytes following cell activation by bacterial lipopolysaccharides and mast cells. Human IL10 is a homodimeric protein that shares 73% amino acid homology with mouse IL10. IL10 inhibits the synthesis of a number of cytokines such as IFN-gamma, IL2 and TNF-beta in Th1 T helper subpopulations of T cells but not of Th2 helper cells. This activity is antagonized by IL4. The inhibitory effect on IFN-gamma production is indirect and appears to be the result of a suppression of IL12 synthesis by accessory cells. In the human system, IL10 is produced by, and down-regulates the function of Th1 and Th2 cells. Source: Recombinant protein corresponding to human IL10 expressed in E. coli. Molecular Weight: ~19kD Biological Activity: The ED50 as determined by the dose-dependent co-stimulation (with murine IL-4) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P22301 |
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| Catalog # | 500098 |
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| Order / More Info | IL10, Recombinant, Human (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF, B-TCGF, TGIF, Interleukin-10) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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