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| Product Name | IL31, Recombinant, Human (IL-31, Interleukin-31) |
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| Description | Purity ~95% (SDS-PAGE). IL-31 is a recently discovered helical cytokine, belonging to the gp130/IL-6 cytokine family. The receptors for IL-6 family are type I receptors, and they share a number of common structural motifs, such as the cytokine-binding domain with two pairs of conserved cysteine residues and a WSXWS sequence motif in the extracellular domain. IL-31 is expressed preferentially by activated Th2 CD4+ T cells, signaling through a heterodimeric receptor complex composed of IL-31RA and OSMR. Recent studies in both humans and mice have suggested a link between IL-31/IL-31R expression and skin inflammation although the functional significance of endogenous IL-31/IL-31R interactions in influencing innate and adaptive immune responses remains unknown. Source: Recombinant protein corresponding to human IL31 expressed in E. coli. Molecular Weight: ~18kD Biological Activity: The ED50 was determined by the ability to induce STAT3 activation in U87 MG cells, and was <7ng/mL. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q6EBC2 |
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| Catalog # | 500154 |
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| Order / More Info | IL31, Recombinant, Human (IL-31, Interleukin-31) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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