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| Product Name | IL17, Recombinant, Mouse |
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| Description | Purity ~95% (SDS-PAGE). Interleukin-17 (IL-17 or IL-17A) is the founder member of the IL-17 cytokine family, which shares 50% homology with IL-17F. IL-17 cytokines are produced by T helper (TH)17 cells, gamma delta T cells, and other immune cells. IL-17A and IL-17F form homodimers and heterodimers as functional ligands. IL-17 cytokines bind to two receptors, IL-17RA and IL-17RC. IL-17RC forms a receptor heterodimer with IL-17RA. The receptor heterodimer is preferred by IL-17 ligands, thus, either IL-17RA knockout (KO) or IL-17RC KO completely abolishes IL-17 signaling. IL-17A and IL-17F are key proinflammatory cytokines involved in many inflammatory and autoimmune diseases. Source: Recombinant protein corresponding to mouse IL17 expressed in E. coli. Molecular Weight: ~16kD Biological Activity: The ED50 was determined by the dose-dependent proliferation of immortalized human gingival keratinocytes (Gie-No3B11) and was found to be <0.5ng/mL. Endotoxin: <1EU/ug (LAL) |
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| Size | 25ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | IL17, Recombinant, Mouse (Interleukin-17A, IL-17, IL-17A, Cytotoxic T-Lymphocyte-Associated Antigen 8, CTLA-8, Ctla8, Il17, Interleukin-17) |
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| Gene, Accession, CAS # | SwissProt: Q62386 |
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| Catalog # | 500111 |
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| Order / More Info | IL17, Recombinant, Mouse from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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