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| Product Name | Klotho beta, Recombinant, Mouse (Beta-klotho, BKL, BetaKlotho, Klotho beta-like Protein) |
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| Description | Purity ≥ 90%, as determined by SDS-PAGE and visualized by silver stain. Klotho b, a divergent structural member of the glycosidase I superfamily, is expressed primarily in the liver and pancreas, with lower expression in adipose tissue.1 Like Klotho, Klotho b facilitates binding between FGF19 subfamily members and their receptors via formation of a ternary complex.2 The Klotho b mediated interaction of FGF15 (human FGF19) with FGF Receptor 4 in the liver negatively regulates bile acid synthesis by controlling the secretion of two key bile acid synthase genes, cholesterol 7-a hydroxylase (Cyp7a1) and sterol 12-a hydroxylase (Cyp8b1).2-4 Klotho b is also a cofactor for the interaction of FGF21 with FGF Receptor 1c in adipocytes, which allows FGF21 to stimulate GLUT1 expression, upregulating adipocyte insulin-dependent glucose uptake.2-3, 5 The 1043 amino acid (aa) type I transmembrane protein is composed of a 51 aa signal sequence, a 943 aa extracellular domain (ECD) containing two glyco |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NP_112457 |
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| Catalog # | K1893-05 |
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| Order / More Info | Klotho beta, Recombinant, Mouse (Beta-klotho, BKL, BetaKlotho, Klotho beta-like Protein) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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