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| Product Name | Klotho (KL), Recombinant, Mouse |
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| Description | Purity >90%, as determined by SDS-PAGE under reducing conditions and visualized by silver stain. Klotho, also called Klotho-a, is the founding member of the Klotho family within the glycosidase-1 superfamily.1, 2 Klotho is expressed in areas concerned with calcium regulation, predominantly in the kidney distal convoluted tubules, but also in the brain choroid plexus (which produces cerebrospinal fluid) and the parathyroid.1 The 1014 amino acid (aa) type I transmembrane protein contains a 34 aa signal sequence, a 948 aa extracellular domain (ECD) containing two extracellular glycosidase-like domains, a 21 aa transmembrane domain and an 11 aa intracellular domain. Within the ECD, mouse Klotho shares 95%, 87% and 87% aa identity with rat, human and equine Klotho, respectively. Although a truncated 554 aa isoform predicts a soluble 70kD form, the soluble form found in plasma and cerebrospinal fluid is a 130kD form produced by proteolytic cleavage of the glycosylated 135kD full-length Kloth |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: AAI38260, SwissProt: O35082 |
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| Catalog # | K1893-04 |
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| Order / More Info | Klotho (KL), Recombinant, Mouse from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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