| 产品详情 |
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| Product Name | KMO Inhibitor I, Ro 61-8048 |
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| Description | Purity ~99% (HPLC). A cell-permeable thiazolylbenzenesulfonamide compound that acts as a potent, competitive and reversible inhibitor of kynurenine-3-monooxygenase activity (Ki=4.8nM; IC50=37nM). Reported to increase the circulating levels of kynurenic acid (KYNA), an excitatory amino acid receptors antagonist, lower reactive oxygen species [ROS], reduce neuronal loss and enhance the survival rate in several neuronal disease models. An orally bioavilable KMO Inhibitor II, JM6, a prodrug of Ro 61-8048 is also available. Formula: C17H15N3O6S2 Molecular Weight: 421.5 Solubility: DMSO (100mg/ml) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | KMO Inhibitor I, Ro 61-8048 (Kynurenine-3-Monooxygenase Inhibitor I, Ro 61-8048 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-benzenesulfonamide Dimethoxy-nitrophenyl-thiazolyl-benzenesulfonamide, Kynurenine-3-Hydroxylase Inhibitor I, Ro 61-8048) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217494 |
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| Order / More Info | KMO Inhibitor I, Ro 61-8048 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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