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| Product Name | KNG1, Recombinant, Human, aa390-644, His-Tag (Kininogen-1) |
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| Description | Purity ~90% (SDS-PAGE). 1 Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clo |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Alpha-2-thiol proteinase inhibitor Fitzgerald factor High molecular weight kininogen, HMWK Williams-Fitzgerald-Flaujeac factor |
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| Gene, Accession, CAS # | SwissProt: P01042 |
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| Catalog # | 373944 |
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| Order / More Info | KNG1, Recombinant, Human, aa390-644, His-Tag (Kininogen-1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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