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| Product Name | FCRN, Recombinant, Mouse, 6-His-Tag |
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| Description | Purity ~95% (SDS-PAGE) under reducing conditions, visualized by silver stain Endotoxin: ≤1.0EU/ug of protein (LAL). The neonatal Fc receptor (FCRN) is an approximately 45kD transmembrane glycoprotein with structural homology to MHC class I proteins. It is widely expressed in endothelial and epithelial cells and plays an important role in IgG homeostasis. Mature mouse FCRN consists of a 276aa extracellular domain (ECD) with two N-terminal alpha domains, one a3/immunoglobulin-like domain, a 24aa transmembrane segment, and a 44aa cytoplasmic domain. Within the ECD, mouse FCRN shares 69% and 91% aa sequence identity with human and rat FCRN, respectively. Mouse FCRN binds with high affinity to IgG from mouse, human, rat, rabbit, guinea pig, bovine, and sheep, while human FCRN binds IgG with significantly lower affinity and is much more restricted in terms of species recognition. It does not bind the structurally related chicken IgG. FCRN additionally binds to albumin, and both it and IgG ar |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | FCRN, Recombinant, Mouse, 6-His-Tag (IgG receptor FcRn Large Subunit p51, FcRn, IgG Fc Fragment Receptor Transporter alpha Chain, Neonatal Fc Receptor, Fcgrt) |
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| Gene, Accession, CAS # | Accession: AAH03786 |
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| Catalog # | F0025-83 |
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| Order / More Info | FCRN, Recombinant, Mouse, 6-His-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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